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The Sign of Four (2001) is a Canadian television film directed by Rodney Gibbons and starring Matt Frewer and Kenneth Welsh. The movie is based on Arthur Conan Doyle's second Sherlock Holmes novel published in 1890.
Unlike the source novel, the movie features Holmes meeting with a Scotland Yard chemist named Professor Morgan who not only identifies the poison which killed Bartholomew Sholto but creates an antidote for Holmes.[3]
The mechanism(s) of Cr(VI)-induced carcinogenicity is not completely understood. The toxicity of chromium within the cell may result from damage to cellular components during the hexavalent to trivalent chromium reduction process, by generation of free radicals, including DNA damage [ATSDR 2000]. Recent studies indicate a biological relevance of non-oxidative mechanisms in Cr(VI) carcinogenesis [Zhitkovich, Song et al. 2001]. 2ff7e9595c
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